A new monograph dedicated to the population genomics of the population has been published in Tashkent, highlighting the critical need to account for national genetic traits in modern healthcare. Researchers collected and analyzed numerous studies to demonstrate that personalized medicine cannot be effectively implemented without considering local genetic profiles.

Global genetic projects reportedly rely heavily on European demographic data, with over 90% of studies in the international GWAS catalog dedicated to Europeans, while Asian groups account for a mere 3.14%. This stark imbalance indicates that applying such generalized research outcomes directly to other ethnic groups, including the population of Uzbekistan, is methodologically problematic.

The authors of the monograph examined 301 publications, providing an in-depth analysis of 34 key works. The book compiles extensive data on hereditary factors associated with cardiovascular diseases, oncological conditions, and metabolic disorders. Special attention is reportedly paid to type 2 diabetes, with researchers claiming that the actual incidence rate in the country is ten times higher than official dispensary statistics suggest.

Based on these findings, scientists have identified genetic risk markers, developed a screening panel, and tested its efficacy. These results could potentially serve as a foundation for creating diagnostic test systems that allow physicians to tailor treatments to individual patient profiles.

The monograph was prepared by the Center for Advanced Technologies in collaboration with the Republican Cardiological Center and the Tashkent State Medical University. It is worth recalling that in October 2025, researchers at the Center for Advanced Technologies purportedly decoded the genomes of citizens for the first time in the nation's history, discovering that nearly a third of the identified mutations were previously unknown to global science.

Source: podrobno.uz